Jipailin can enhance the inhibitory activity of anti-thrombin III (ATIII) against factor Xa and thrombin by binding to ATIII and its complexes. Due to its shorter mucopolysaccharide chain, Jipailin has higher inhibitory activity against Xa than against thrombin. The ratio of anti-factor Xa/anti-factor IIa of Jipailin is 3:1 to 4:1, while that of UFH(unfractionated heparin) is 1:1 (See Figure: Mechanism Comparison between Jipailin and UFH).

In several experimental models in rabbits and mice, whether i.v. or s.c., Jipailin demonstrates significant antithrombotic activity, similar or higher than UFH. Jipailin shows less anticoagulation activity than UFH.